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Onychomycosis and penetration

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Limited pharmacologic treatment options exist for onychomycosis, especially for patients who wish to avoid or are unable to take oral antifungal medication. Nail debridement has been an integral part of therapeutic studies examining the efficacy of ciclopirox. Despite concomitant nail debridement, the efficacy of ciclopirox for the treatment of onychomycosis is very poor. Two parallel, double-blind, randomized phase III trials, — in which study participants applied efinaconazole daily for 48 weeks without nail debridement — showed mycological and complete cure rates two to three times greater than those for ciclopirox, and comparable to 12 weeks of oral itraconazole. In these studies, researchers considered 40 to 45 percent of patients as having treatment successes. They defined treatment success as an affected target toenail area of less than 10 percent.
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Maximizing topical toenail fungus therapy

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Two New Topical Antifungals for Onychomycosis - LECOM Education System

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Challenges and Opportunities in the Management of Onychomycosis

Fungal infections of skin are one of the most common infections in human beings. The areas which are likely to get infected include the scalp, the hands and the feet. Dermatophytes, yeasts and moulds are the three major fungi responsible for skin infections. Earlier oral antifungal agents were used for treatment of fungal infection in finger and toe nails.
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PLoS Pathog 10 6 : e Editor: William E. This is an open-access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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